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RNF125 Antibodies
AND RNF125 ELISA kits, RNF125 Proteins
Many biological assays use antibodies to detect RNF125, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RNF125 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RNF125 antibodies...
Designing an IHC experiment for RNF125? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the RNF125 IHC GuideRNF125 Infographic by Boster Bio
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RNF125 Overview
Facts about E3 ubiquitin-protein ligase RNF125.
E3 ubiquitin-protein ligase RNF125 (RNF125)
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53 (PubMed:15843525, PubMed:17460044, PubMed:17643463, PubMed:26027934, PubMed:26471729, PubMed:25591766, PubMed:27411375). Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I in'Lys-181', leading to DDX58/RIG-I degradation (PubMed:17460044, PubMed:26471729).
Mediates ubiquitination and subsequent degradation of p53/TP53 (PubMed:25591766). Mediates ubiquitination and subsequent degradation of JAK1 (PubMed:26027934).
Gene Information
| Human | |
|---|---|
| Gene Name: | RNF125 |
| Uniprot: | Q96EQ8 |
| Entrez: | 54941 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
E3 ubiquitin-protein ligase RNF125; EC 6.3.2.-; FLJ20456; MGC21737; ring finger protein 125TRAC1; T-cell RING activation protein 1; T-cell ring protein identified in activation screen; TRAC-1
Molecular Weight
Mass (kDA):
26.454 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q12.1 |
| Sequence: | 18; NC_000018.10 (32018585..32090756) |
Tissue Specificity
Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4(+) and CD8(+) T-cells, suggesting that it is preferentially confined to T-cells.
Subcellular Localizations
Golgi apparatus membrane; Lipid-anchor. Shows a reticular staining pattern within the cell and is probably expressed at other intracellular membranes in addition to the Golgi membrane. Not detected at the plasma membrane.
Diseases
- Innate Immune Response
- Hepatitis, Chronic
- Hepatitis C, Chronic
- Malignant Neoplasms
- Neoplasms
- Hepatitis
- Hepatitis C
- Cholangiocarcinoma
- Neoplasm Metastasis
- Metastatic Malignant Neoplasm To The Lymph Node
- Metastatic Malignant Neoplasm To The Lung
- Stomatitis
- Sarcoma
Interacting Proteins
- IFIH1
- UBE2E2
Pathways
- Cytokine Production
- Innate Immune Response
- Immune Response
- Conjugation
- Cell Adhesion
- Cell Activation
- Viral Transcription
- Cell Cycle
PTMs
- Ubiquitination
- Isgylation
Research Areas
- Zinc Finger
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RNF125
bosterbio.com/bosterbio-gene-info-cards/RNF125
References
PMID: 12974981 by Chu P., et al. Systematic identification of regulatory proteins critical for T-cell activation.
PMID: 15843525 by Zhao H., et al. A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation.