E3 ubiquitin-protein ligase RNF165 (Rnf165)

E3 ubiquitin-protein ligase that serves as a regulator of motor axon elongation (PubMed:23610558). Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which can be activated downstream of BMP (PubMed:23610558).

Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL (PubMed:23610558). .