RNF182 Antibodies

AND RNF182 ELISA kits, RNF182 Proteins

Many biological assays use antibodies to detect RNF182, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RNF182 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RNF182 antibodies...

We validate the specificity of these antibodies to RNF182 by testing them on tissues known to express RNF182 positively and negatively. Browse below to find the RNF182 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RNF182 Infographic by Boster Bio

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RNF182 (NM_001165032) Human Over-expression Lysate

Human

$628
Cat # LS221687
20 µg, 100 µg

RNF182 Overview

Facts about E3 ubiquitin-protein ligase RNF182.

RNF182 3D structure. Source: alphafold

E3 ubiquitin-protein ligase RNF182 (RNF182)

E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. .

Gene Information

Human
Gene Name:	RNF182
Uniprot:	Q8N6D2
Entrez:	221687

Family

Belongs to:

No superfamily

Alternative Names

E3 ubiquitin-protein ligase RNF182; EC 6.3.2.-; FLJ40772; ring finger protein 182MGC33993

Molecular Weight

Mass (kDA):
27.402 kDA

Genomic Context


Human

Location:	6p23
Sequence:	6; NC_000006.12 (13924446..13980310)

Tissue Specificity

Up-regulated in neuronal cells subjected to cell death-inducing injuries, such as oxygen and glucose deprivation (at protein level). Could be up-regulated in Alzheimer disease brains.

Subcellular Localizations

Membrane; Multi-pass membrane protein. Cytoplasm.

Diseases

Rett Syndrome
Nerve Degeneration
Alzheimer's Disease
Embryonic Mosaic

Interacting Proteins

UBE2N

Pathways

Cell Death
Cellular Homeostasis
Pathogenesis
Protein Processing

Research Areas

Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RNF182

References

PMID: 18298843 by Liu Q.Y., et al. A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation.

PMID: 31432514 by Cao Y., et al. The E3 ubiquitin ligase RNF182 inhibits TLR-triggered cytokine production through promoting p65 ubiquitination and degradation.