RNFT1 Antibodies

AND RNFT1 ELISA kits, RNFT1 Proteins

Many biological assays use antibodies to detect RNFT1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RNFT1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RNFT1 antibodies...

We validate the specificity of these antibodies to RNFT1 by testing them on tissues known to express RNFT1 positively and negatively. Browse below to find the RNFT1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RNFT1 Infographic by Boster Bio

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RNFT1 Overview

Facts about E3 ubiquitin-protein ligase RNFT1.

RNFT1 3D structure. Source: alphafold

E3 ubiquitin-protein ligase RNFT1 (RNFT1)

E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome- mediated degradation. Protects cells from ER stress-induced apoptosis.

Gene Information

Human
Gene Name:	RNFT1
Uniprot:	Q5M7Z0
Entrez:	51136

Family

Belongs to:

No superfamily

Alternative Names

MGC111090; Protein PTD016; PTD016; RING finger and transmembrane domain-containing protein 1; ring finger protein, transmembrane 1

Molecular Weight

Mass (kDA):
49.71 kDA

Genomic Context


Human

Location:	17q23.1
Sequence:	17; NC_000017.11 (59952240..59964740, complement)

Tissue Specificity

Expressed at highest levels in testis, lower levels in heart, liver, lung, and kidney (PubMed:17074343). Not detected in brain, ovary, and uterus (PubMed:17074343). Down- regulated in testis from patients with maturation arrest (MA) or Sertoli cell-only syndrome (SCOS) (PubMed:17074343). Ubiquitously expressed with high expression in testis (PubMed:27485036).

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein.

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RNFT1

References

PMID: 17074343 by Lin Y.H., et al. Identification of ten novel genes involved in human spermatogenesis by microarray analysis of testicular tissue.

PMID: 27485036 by Kaneko M., et al. Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation.