Nuclear receptor ROR-beta (RORB)

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a brief A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands like all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity.

Required for normal postnatal maturation of rod and cone photoreceptor cells. Modulates rod photoreceptors distinction at least by inducing the transcription factor NRL-mediated pathway.