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- Table of Contents
RPS6KA4 Antibodies
AND RPS6KA4 ELISA kits, RPS6KA4 Proteins
Many biological assays use antibodies to detect RPS6KA4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RPS6KA4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RPS6KA4 antibodies...
Designing a Western blot for RPS6KA4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RPS6KA4 Western Blot GuideRPS6KA4 Infographic by Boster Bio
All RPS6KA4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A05545-2
100 μg/vial
Cat # A05545-2
100 μg/vial
Human
$960
Cat # LS008986
20 µg, 100 µg
Cat # LS008986
20 µg, 100 µg
Human, Mouse
ELISA
$480
Cat # EKC1387
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1387
1 kit, containing one 96-well plate and all necessary reagents
RPS6KA4 Overview
Facts about Ribosomal protein S6 kinase alpha-4.
Ribosomal protein S6 kinase alpha-4 (RPS6KA4)
Serine/threonine-protein kinase that's required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, which contributes to gene activation by histone phosphorylation and works in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli like UV-C irradiation, epidermal growth factor (EGF) and anisomycin.
Plays an important role in the control of RELA transcriptional activity in response to TNF. Phosphorylates'Ser-10' of histone H3 in reaction to mitogenics, stress stimulation and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN.
Gene Information
| Human | |
|---|---|
| Gene Name: | RPS6KA4 |
| Uniprot: | O75676 |
| Entrez: | 8986 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
MSK2; ribosomal protein S6 kinase, 90kDa, polypeptide 4; RPS6KA4; RSKB
Molecular Weight
Mass (kDA):
85.606 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.1 |
| Sequence: | 11; NC_000011.10 (64359162..64372215) |
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Psoriasis
- Physiological Stress
- Inflammation
- Carcinogenesis
- Contact Dermatitis
- Cholangiocarcinoma
- Neoplasm Metastasis
- Neoplasms, Second Primary
- Uterine Cervical Neoplasm
- Hypoxia
- Teratocarcinoma
Interacting Proteins
- MAPK14
Pathways
- Cytokine Production
- Pathogenesis
- Response To Stress
- Chromatin Remodeling
- Protein Phosphorylation
- Response To Anisomycin
- Immune Response
- Cell Cycle Arrest
- Histone H3 Acetylation
- Translation
- Cell Cycle
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RPS6KA4
bosterbio.com/bosterbio-gene-info-cards/RPS6KA4
References
PMID: 9792677 by Pierrat B., et al. RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK).
PMID: 9687510 by Deak M., et al. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.