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- Table of Contents
RTCA Antibodies
AND RTCA ELISA kits, RTCA Proteins
Many biological assays use antibodies to detect RTCA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RTCA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RTCA antibodies...
Designing a Western blot for RTCA? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RTCA Western Blot GuideDesigning an IHC experiment for RTCA? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the RTCA IHC GuideRTCA Infographic by Boster Bio
All RTCA Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A07570-1
100 μg/vial
Cat # A07570-1
100 μg/vial
RTCA Overview
Facts about RNA 3'-terminal phosphate cyclase.
RNA 3'-terminal phosphate cyclase (RTCA)
Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of this enzyme occurs in 3 steps: (A) adenylation of this enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA- N3'PP5'A; (C) and assault of the adjacent 2'-hydroxyl on the 3'- phosphorus at the diester linkage to generate the cyclic end product.
The biological role of this enzyme is unknown but it is very likely to function in some aspects of cellular RNA processing. .
Gene Information
| Human | |
|---|---|
| Gene Name: | RTCA |
| Uniprot: | O00442 |
| Entrez: | 8634 |
Family
| Belongs to: |
|---|
| RNA 3'-terminal cyclase family |
Alternative Names
phosphate cyclase; RNA 3'-terminal phosphate cyclase; RNA cyclase; RNA terminal phosphate cyclase domain 1; RNA terminal phosphate cyclase domain-containing protein 1; RNA-3'-phosphate cyclase; RPC1; RPCEC 6.5.1.4; RTC domain containing 1; RTC domain-containing protein 1; RTC1
Molecular Weight
Mass (kDA):
39.337 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p21.2 |
| Sequence: | 1; NC_000001.11 (100266158..100292769) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Nucleus, nucleoplasm.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Lung
- Influenza
- Cardiac Arrhythmia
- Influenza Due To Influenza A Virus Subtype H1n1
- Malignant Neoplasm Of Breast
- Exudative Age-related Macular Degeneration
- Age Related Macular Degeneration
- Tumor Angiogenesis
- Neoplasms
- Pathologic Neovascularization
- Cell Invasion
Pathways
- Cell Growth
- Cell Proliferation
- Reductive Tricarboxylic Acid Cycle
- Cytolysis
- Cell Migration
- Tricarboxylic Acid Cycle
- Induction Of Apoptosis
- Tube Formation
- Angiogenesis
- Rna Repair
- Immune Response
PTMs
- Cleavage
- Phosphorylation
- Carboxylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RTCA
bosterbio.com/bosterbio-gene-info-cards/RTCA
References
PMID: 9184239 by Genschik P., et al. The human RNA 3'-terminal phosphate cyclase is a member of a new family of proteins conserved in Eucarya, Bacteria and Archaea.
PMID: 2199762 by Filipowicz W., et al. RNA 3'-terminal phosphate cyclase from HeLa cells.