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- Table of Contents
Reticulon-4 Antibodies
AND RTN4 ELISA kits, Reticulon-4 Proteins
Many biological assays use antibodies to detect Reticulon-4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Reticulon-4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Reticulon-4 antibodies...
Designing a Western blot for Reticulon-4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RTN4 Western Blot GuideRTN4 Infographic by Boster Bio
All RTN4 Products
Product
Figures
Specificity
Applications
Price
Anti-Nogo A/RTN4 Antibody Picoband®
4 Citations
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01844-2
100 μg/vial
Cat # A01844-2
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A13135-1
100 µg/vial
Cat # A13135-1
100 µg/vial
Anti-Nogo receptor/NgR1/RTN4R Antibody Picoband®
1 Citations
Human, Mouse, Rat
ELISA, WB
$370
Cat # A02250-2
100 µg/vial
Cat # A02250-2
100 µg/vial
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01844-2
100 μg
Cat # M01844-2
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01804-2
100 μg
Cat # M01804-2
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01804-1
100 μg
Cat # M01804-1
100 μg
Human, Rat
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M02250-1
100 μg
Cat # M02250-1
100 μg
Human
$628
Cat # LS065078
20 µg, 100 µg
Cat # LS065078
20 µg, 100 µg
RTN4 Overview
Facts about Reticulon-4.
Reticulon-4 (RTN4)
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and expansion in the developing nervous system.
Involved in down-regulation of development, insertion of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons through an RTN4R-LINGO1 containing receptor complex (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | RTN4 |
| Uniprot: | Q9NQC3 |
| Entrez: | 57142 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ASY; foocen; Human NogoA; KIAA0886; My043 protein; Nbla00271; Nbla10545; neurite growth inhibitor 220; Neurite outgrowth inhibitor; Neuroendocrine-specific protein C homolog; Neuroendocrine-specific protein; NI220/250; Nogo protein; NOGO-A; Nogo-B; NOGOC; Nogo-C; NOGORTN4-B1; NSP; NSP-CL; reticulon 4; reticulon 5; reticulon-4; reticulon-5; RTN4-A; RTN4-B2; RTN4-C; RTN-x
Molecular Weight
Mass (kDA):
129.931 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p16.1 |
| Sequence: | 2; NC_000002.12 (54972189..55137831, complement) |
Tissue Specificity
Isoform 1 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 is widely expressed except for the liver. Isoform 3 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 is testis- specific.
Subcellular Localizations
[Isoform A]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein; Cytoplasmic side. Anchored to the membrane of the endoplasmic reticulum (ER) through 2 putative transmembrane domains. Localizes throughout the ER tubular network (PubMed:27619977). Co-localizes with TMEM33 at the ER sheets.; [Isoform B]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein; Extracellular side. Cell junction. Mainly located on endoplasmic reticulum tubules and sheet edges (PubMed:27786289). Upon ICAM1 engagemen
Diseases
- Nervousness
- Schizophrenia
- Alzheimer's Disease
- Neoplasms
- Neurodegenerative Disorders
- Tissue Adhesions
- Sclerosis
- Primary Lateral Sclerosis
- Amyotrophic Lateral Sclerosis
- Heart Diseases
- Depressive Disorder
- Rheumatic Heart Disease
- Impaired Cognition
Interacting Proteins
- ARL6IP1
- ATL1
- NCK2
- SNX1
- SNX15
- SYT16
- ZFYVE21
Pathways
- Regeneration
- Pathogenesis
- Cell Migration
- Localization
- Cell Adhesion
- Axon Regeneration
- Neurogenesis
- Cell Division
- Cell Death
- Membrane Organization
- Cerebellum Development
- Chemotaxis
- Translation
PTMs
- Phosphorylation
- Cleavage
Research Areas
- Apoptosis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RTN4
bosterbio.com/bosterbio-gene-info-cards/RTN4
References
PMID: 10773680 by Yang J., et al. Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping.
PMID: 10667780 by Prinjha R., et al. Inhibitor of neurite outgrowth in humans.