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- Table of Contents
RYBP Antibodies
AND RYBP ELISA kits, RYBP Proteins
Many biological assays use antibodies to detect RYBP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RYBP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RYBP antibodies...
Designing a Western blot for RYBP? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RYBP Western Blot GuideDesigning an IHC experiment for RYBP? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the RYBP IHC GuideRYBP Infographic by Boster Bio
All RYBP Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M04316-3
100 μl/vial
Cat # M04316-3
100 μl/vial
RYBP Overview
Facts about RING1 and YY1-binding protein.
RING1 and YY1-binding protein (RYBP)
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, during development. PcG PRC1-like complex acts through chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132).
Component of a PRC1-like complex that mediates monoubiquitination of histone H2A'Lys-119' on the X chromosome and is needed for normal silencing of a single copy of the X chromosome in XX females. Inhibits ubiquitination and subsequent degradation of TP53, and thus plays a role in regulating transcription of TP53 target genes (PubMed:19098711).
Gene Information
| Human | |
|---|---|
| Gene Name: | RYBP |
| Uniprot: | Q8N488 |
| Entrez: | 23429 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AAP1; APAP-1; Apoptin-associating protein 1; Death effector domain-associated factor; DEDAFYY1 and E4TF1-associated factor 1; RING1 and YY1 binding protein; RING1 and YY1-binding protein; ring1 interactor RYBP; YEAF1DED-associated factor; YY1 and E4TF1 associated factor 1
Molecular Weight
Mass (kDA):
24.822 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p13 |
| Sequence: | 3; NC_000003.12 (72374593..72446623, complement) |
Tissue Specificity
Down-regulated in breast cancer tissues and in several breast cancer cell lines (at protein level) (PubMed:27748911). Widely expressed with highest levels in lymphoid tissues and placenta.
Subcellular Localizations
Nucleus. Cytoplasm. Nucleus, nucleoplasm. Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity).
Diseases
- Malignant Neoplasms
- Neoplasms
- Lymphoma
- Cell Transformation, Neoplastic
- Nervousness
- Hodgkin Disease
- Hyperplasia
- Esophageal Motility Disorders
- Adenoma
- Neoplasm Metastasis
- Liver Abscess
- Atresia
- Abscess
Interacting Proteins
- MDM2
- RING1
- RNF2
- TP53
- Trpm7
- UBC
Pathways
- Localization
- Gene Silencing
- Cell Differentiation
- Pathogenesis
- Neural Tube Closure
- Translation
- Cell Cycle
- Cell Proliferation
- Tube Closure
- Muscle Cell Differentiation
- Macromolecule Localization
- Stem Cell Maintenance
- Plasma Cell Differentiation
PTMs
- Methylation
Research Areas
- Apoptosis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RYBP
bosterbio.com/bosterbio-gene-info-cards/RYBP
References
PMID: 11395500 by Zheng L., et al. The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm.
PMID: 11953439 by Sawa C., et al. YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors.