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Rab7b Antibodies
AND Rab7b ELISA kits, Rab7b Proteins
Many biological assays use antibodies to detect Rab7b, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Rab7b in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Rab7b antibodies...
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Rab7b Overview
Facts about Ras-related protein Rab-7b.
Ras-related protein Rab-7b (Rab7b)
Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation.
Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by raising NF-kappa-B-dependent IL6 production and then enhancing the association of STAT3 with GATA1.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Rab7b |
| Uniprot: | Q8VEA8 |
| Entrez: | 226421 |
Family
| Belongs to: |
|---|
| small GTPase superfamily |
Alternative Names
MGC16212; MGC9726; RAB7; RAB7B, member RAS oncogene family; Ras-related protein Rab-7; ras-related protein Rab-7b
Molecular Weight
Mass (kDA):
22.502 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 1|1 E4 |
| Sequence: | 1; |
Diseases
- Dementia
- Autoimmune Reaction
- Lewy Body Disease
- Leukemia
- Alzheimer's Disease
- Pick Disease Of The Brain
- Neurodegenerative Disorders
- Cholera
- Stomatitis
- Autoimmune Diseases
- Vesicular Stomatitis
- Progressive Supranuclear Palsy
Pathways
- Transport
- Localization
- Pathogenesis
- Cell Differentiation
- Phagosome Formation
- Gene Silencing
- Phagosome Maturation
- Glycosylation
- Endocytosis
PTMs
- Glycosylation
Research Areas
- Endosome Markers
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Rab7b
bosterbio.com/bosterbio-gene-info-cards/Rab7b
References
PMID: 16923123 by Itoh T., et al. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity.
PMID: 17395780 by Wang Y., et al. Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4.