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- Table of Contents
RB1 Antibodies
AND RB1 ELISA kits, RB1 Proteins
Many biological assays use antibodies to detect RB1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RB1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RB1 antibodies...
Designing a Western blot for RB1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RB1 Western Blot GuideDesigning an IHC experiment for RB1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the RB1 IHC GuideRB1 Infographic by Boster Bio
All RB1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
IP, IF, IHC, ICC, WB
$370
Cat # M00039-2
100 μl
Cat # M00039-2
100 μl
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00039-3
100 μg/vial
Cat # A00039-3
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02414-1
100 μg/vial
Cat # A02414-1
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # P00039-1
100 μl
Cat # P00039-1
100 μl
Human
IHC, WB
$370
Cat # M00039-1
100 μl
Cat # M00039-1
100 μl
Human, Mouse, Rat
ELISA
$540
Cat # EKC2503
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2503
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2502
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2502
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2501
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2501
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2270
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2270
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2209
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2209
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1500
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1500
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA
$480
Cat # EKC1826
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1826
1 kit, containing one 96-well plate and all necessary reagents
RB1 Overview
Facts about Retinoblastoma-associated protein.
Retinoblastoma-associated protein (RB1)
Key regulator of entry into mobile division that serves as a tumor suppressor. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest.
Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression.
Gene Information
| Human | |
|---|---|
| Gene Name: | RB1 |
| Uniprot: | P06400 |
| Entrez: | 5925 |
Family
| Belongs to: |
|---|
| retinoblastoma protein (RB) family |
Alternative Names
OSRC; osteosarcoma; p105-Rb; pp110; pRb; RB; RB1; retinoblastoma 1; retinoblastoma suspectibility protein; retinoblastoma-associated protein
Molecular Weight
Mass (kDA):
106.159 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q14.2 |
| Sequence: | 13; NC_000013.11 (48303751..48481890) |
Tissue Specificity
Expressed in the retina.
Subcellular Localizations
Nucleus. During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization.
Diseases
- Neoplasms
- Retinoblastoma
- Malignant Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Retinal Neoplasms
- Leukemia
- Cytogenetic Abnormality
- Malignant Neoplasm Of Breast
- Eye Neoplasms
- Neoplasm Metastasis
- Mammary Neoplasms
Interacting Proteins
- AGO2
- CCNC
- CDK2
- Cdk4
- CHEK1
- CHEK2
- DYRK1A
- DYRK1B
- E2F1
- E2F2
Pathways
- Cell Cycle
- Methylation
- Pathogenesis
- Cell Proliferation
- Cell Growth
- Interphase
- Dna Methylation
- Localization
- Dna Repair
- Oncogenesis
- Senescence
- S Phase
- Cell Death
PTMs
- Methylation
- Phosphorylation
- Cleavage
- Acetylation
- Demethylation
- Reduction
- Ubiquitination
- Dephosphorylation
- Deglycosylation
Research Areas
- Cancer
- Cell Cycle and Replication
- Transcription Factors and Regulators
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RB1
bosterbio.com/bosterbio-gene-info-cards/RB1
References
PMID: 3657987 by Lee W.-H., et al. The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity.
PMID: 3823889 by Lee W.-H., et al. Human retinoblastoma susceptibility gene: cloning, identification, and sequence.
1 Publications of Boster RB1 Antibodies & ELISA Kits
- PubMed ID: 26379831, Effects of sericin on the testicular growth hormone/insulin-like growth factor-1...
*More publications can be found for each product on its corresponding product page