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- Table of Contents
Facts about Ras and Rab interactor 2.
May function as a guanine nucleotide exchange (GEF) of RAB5B, required for triggering the RAB5 proteins by exchanging bound GDP for free GTP. .
| Human | |
|---|---|
| Gene Name: | RIN2 |
| Uniprot: | Q8WYP3 |
| Entrez: | 54453 |

| Belongs to: |
|---|
| RIN (Ras interaction/interference) family |

RAB5 interacting protein 2; Ras and Rab interactor 2; RAS association (RalGDS/AF-6) domain containing protein JC265; Ras association domain family 4; Ras inhibitor JC265; Ras interaction/interference protein 2; RASSF4MACS
Mass (kDA):
100.163 kDA

| Human | |
|---|---|
| Location: | 20p11.23 |
| Sequence: | 20; NC_000020.11 (19757610..20002459) |
Widely expressed. Expressed in heart, kidney, lung placenta. Expressed at low level in skeletal muscle, spleen and peripheral blood.
Cytoplasm.





PMID: 11733506 by Saito K., et al. A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5.
PMID: 1849280 by Colicelli J., et al. Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae.