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Rnf168 Antibodies
AND Rnf168 ELISA kits, Rnf168 Proteins
Many biological assays use antibodies to detect Rnf168, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Rnf168 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Rnf168 antibodies...
Designing a Western blot for Rnf168? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RNF168 Western Blot GuideRnf168 Infographic by Boster Bio
All Rnf168 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01224-1
100 μg/vial
Cat # A01224-1
100 μg/vial
Rnf168 Overview
Facts about E3 ubiquitin-protein ligase RNF168.
E3 ubiquitin-protein ligase RNF168 (Rnf168)
E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination.
Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8- dependent H2A ubiquitination, promoting the creation of'Lys-63'- linked ubiquitin conjugates. This leads to focus ubiquitinated histones H2A and H2AX in DNA lesions to the threshold necessary for recruitment of TP53BP1 and BRCA1.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Rnf168 |
| Uniprot: | Q80XJ2 |
| Entrez: | 70238 |
Family
| Belongs to: |
|---|
| RNF168 family |
Alternative Names
E3 ubiquitin-protein ligase RNF168; EC 6.3.2; EC 6.3.2.-; FLJ39749; ring finger protein 168FLJ35794; RNF168
Molecular Weight
Mass (kDA):
64.779 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 16|16 B3 |
| Sequence: | 16; |
Diseases
- Malignant Neoplasms
- Genomic Instability
- Neoplasms
- Immunologic Deficiency Syndromes
- Ataxia Telangiectasia
- Malignant Neoplasm Of Breast
- Ataxia
- Cell Transformation, Neoplastic
- Telangiectasis
- Fanconi Anemia
- Premature Aging Syndrome
- Chromosome Breakage
Pathways
- Dna Repair
- Cell Cycle
- Localization
- Double-strand Break Repair
- Cell Division
- Chromatin Remodeling
- Conjugation
- Histone Ubiquitination
- Aging
- V(d)j Recombination
- Dna Damage Checkpoint
- Mitosis
- Dna Replication
PTMs
- Phosphorylation
- Ubiquitination
- Sumoylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Rnf168
bosterbio.com/bosterbio-gene-info-cards/Rnf168
References
PMID: 20080757 by Ramachandran S., et al. The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination.