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- Table of Contents
Protein S100-P Antibodies
AND S100P ELISA kits, Protein S100-P Proteins
Many biological assays use antibodies to detect Protein S100-P, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein S100-P in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein S100-P antibodies...
Designing an IHC experiment for Protein S100-P? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the S100P IHC GuideS100P Infographic by Boster Bio
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S100P Overview
Facts about Protein S100-P.
Protein S100-P (S100P)
May be the calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent fashion, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells.
May stimulate cell proliferation in an autocrine manner via activation of this receptor for activated glycation end products (RAGE). .
Gene Information
| Human | |
|---|---|
| Gene Name: | S100P |
| Uniprot: | P25815 |
| Entrez: | 6286 |
Family
| Belongs to: |
|---|
| S-100 family |
Alternative Names
MIG9; migration-inducing gene 9; Protein S100-E; S100 calcium binding protein P; S100 calcium-binding protein Pprotein S100-P; S100E; S100P
Molecular Weight
Mass (kDA):
10.4 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4p16.1 |
| Sequence: | 4; NC_000004.12 (6693878..6697170) |
Tissue Specificity
Detected in all of the tissues except brain, testis and small intestine, expression level is higher in placenta, heart, lung, skeletal muscle, spleen and leukocyte. Up- regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias.
Subcellular Localizations
Nucleus. Cytoplasm. Cell projection, microvillus membrane. Colocalizes with S100PBP in the nucleus. Colocolizes with EZR in the microvilli in a calcium-dependent manner.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Adenocarcinoma
- Neoplasm Metastasis
- Pancreatic Neoplasm
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Cell Invasion
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Pancreas
- Mammary Neoplasms
Interacting Proteins
- AGER
- Cacybp
- IL11
- S100A1
- S100B
- TERF2IP
- TFIP11
Pathways
- Cell Proliferation
- Cell Growth
- Methylation
- Cell Cycle
- Pathogenesis
- Localization
- Dna Methylation
- Cell Migration
- Cell Differentiation
- Rna Interference
- Cell Adhesion
- Gene Silencing
- Dna Hypomethylation
PTMs
- Phosphorylation
- Methylation
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/S100P
bosterbio.com/bosterbio-gene-info-cards/S100P
References
PMID: 1633809 by Becker T., et al. S100P, a novel Ca(2+)-binding protein from human placenta. cDNA cloning, recombinant protein expression and Ca2+ binding properties.
PMID: 1540168 by Emoto Y., et al. Purification and characterization of a new member of the S-100 protein family from human placenta.