S1PR5 Antibodies

AND S1PR5 ELISA kits, S1PR5 Proteins

Many biological assays use antibodies to detect S1PR5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with S1PR5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop S1PR5 antibodies...

We validate the specificity of these antibodies to S1PR5 by testing them on tissues known to express S1PR5 positively and negatively. Browse below to find the S1PR5 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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S1PR5 Infographic by Boster Bio

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EDG8 (S1PR5) (NM_030760) Human Over-expression Lysate

Human

$628
Cat # LS053637
20 µg, 100 µg

S1PR5 Overview

Facts about Sphingosine 1-phosphate receptor 5.

S1PR5 3D structure. Source: alphafold

Sphingosine 1-phosphate receptor 5 (S1PR5)

Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.

Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells.

Gene Information

Human
Gene Name:	S1PR5
Uniprot:	Q9H228
Entrez:	53637

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

EDG8; Edg-8; EDG8S1P receptor Edg-8; Endothelial differentiation G-protein-coupled receptor 8; endothelial differentiation, sphingolipid G-protein-coupled receptor, 8; LPB4; S1P receptor 5; S1P5; S1PR5; sphingosine 1-phosphate receptor 5; sphingosine 1-phosphate receptor EDG8; Sphingosine 1-phosphate receptor Edg-8; sphingosine-1-phosphate receptor 5; SPPR-1; SPPR-2

Molecular Weight

Mass (kDA):
41.775 kDA

Genomic Context


Human

Location:	19p13.2
Sequence:	19; NC_000019.10 (10512742..10517965, complement)

Tissue Specificity

Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Malignant Neoplasms
Salivary Gland Neoplasms
Developmental Delay (disorder)
Graft-vs-host Disease
Pediatric Obesity
Lung Diseases
Acute Gvh Disease
Crest Syndrome
Carcinoma
Chronic Obstructive Airway Disease
Lung Diseases, Obstructive
Pneumonia

Tumor Angiogenesis
Chronic Graft Versus Host Disease
Neoplasms
Obesity
Adenoid Cystic Carcinoma
Nervousness
Pertussis

Pathways

Cell Migration
Methylation
Dna Methylation
Angiogenesis

PTMs

Methylation

Research Areas

GPCR

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/S1PR5

References

PMID: 12427546 by Kothapalli R., et al. Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia.

PMID: 11705398 by Im D.-S., et al. Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors.