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- Table of Contents
NAD(+) hydrolase SARM1 Antibodies
AND SARM1 ELISA kits, NAD(+) hydrolase SARM1 Proteins
Many biological assays use antibodies to detect NAD(+) hydrolase SARM1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NAD(+) hydrolase SARM1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NAD(+) hydrolase SARM1 antibodies...
Designing a Western blot for NAD(+) hydrolase SARM1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SARM1 Western Blot GuideSARM1 Infographic by Boster Bio
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SARM1 Overview
Facts about NAD(+) hydrolase SARM1.
NAD(+) hydrolase SARM1 (SARM1)
Negative regulator of MYD88- and TRIF-dependent toll- like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site.
Can trigger neuronal death in response to anxiety. Regulates dendritic arborization through the MAPK4-JNK pathway.
Gene Information
| Human | |
|---|---|
| Gene Name: | SARM1 |
| Uniprot: | Q6SZW1 |
| Entrez: | 23098 |
Family
| Belongs to: |
|---|
| SARM1 family |
Alternative Names
KIAA0524SAM domain-containing protein 2; SAMD2; SAMD2sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; SARM1; SARMFLJ36296; Sterile alpha and Armadillo repeat protein; sterile alpha and TIR motif containing 1; sterile alpha and TIR motif-containing protein 1; Sterile alpha motif domain-containing protein 2; Tir-1 homolog
Molecular Weight
Mass (kDA):
79.388 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q11.2 |
| Sequence: | 17; NC_000017.11 (28371694..28404049) |
Tissue Specificity
Predominantly expressed in brain, kidney and liver. Expressed at lower level in placenta.
Subcellular Localizations
Cytoplasm. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse. Mitochondrion. Associated with microtubules.
Diseases
- Communicable Diseases
- Malignant Neoplasms
- Bacterial Infections
- Inflammation
- Neurodegenerative Disorders
- Age Related Macular Degeneration
- Innate Immune Response
- Wallerian Degeneration
- Mycoses
- Colorectal Cancer
- Porcine Reproductive And Respiratory Syndrome
- Brain Injuries
- Infective Disorder
Interacting Proteins
- MYD88
- TICAM2
Pathways
- Immune Response
- Localization
- Cell Adhesion
- Blood Coagulation
- Cytokine Secretion
- Signalosome Assembly
- Coagulation
- Calcium-mediated Signaling
- Cell Death
- Cellular Localization
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SARM1
bosterbio.com/bosterbio-gene-info-cards/SARM1
References
PMID: 11386760 by Mink M., et al. A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to Armadillo/beta-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegans.
PMID: 15123841 by Liberati N.T., et al. Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.