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- Table of Contents
Facts about Sodium channel subunit beta-3.
Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and keep these channels at the nodes in mature myelinated axons (By similarity).
Human | |
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Gene Name: | SCN3B |
Uniprot: | Q9NY72 |
Entrez: | 55800 |
Belongs to: |
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sodium channel auxiliary subunit SCN3B (TC 8.A.17) family |
HSA243396; KIAA1158; SCNB3; sodium channel subunit beta-3; sodium channel, voltage-gated, type III, beta; voltage-gated sodium channel beta-3 subunit
Mass (kDA):
24.702 kDA
Human | |
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Location: | 11q24.1 |
Sequence: | 11; NC_000011.10 (123629187..123654607, complement) |
Expressed in the atrium.
Membrane; Single-pass type I membrane protein.
PMID: 10688874 by Morgan K., et al. Beta3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics.
PMID: 20031595 by Hu D., et al. A mutation in the beta-3 subunit of the cardiac sodium channel associated with Brugada ECG phenotype.