SCN3B Antibodies

AND SCN3B ELISA kits, SCN3B Proteins

Many biological assays use antibodies to detect SCN3B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SCN3B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SCN3B antibodies...

We validate the specificity of these antibodies to SCN3B by testing them on tissues known to express SCN3B positively and negatively. Browse below to find the SCN3B antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SCN3B Infographic by Boster Bio

All SCN3B Products

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Specificity

Applications

Price

SCN3B (NM_001040151) Human Recombinant Protein

$1249
Cat # PROTQ9NY72
20 µg

SCN3B (NM_018400) Human Over-expression Lysate

SCN3B Human Over-expression Lysates NM_001040151

Human

$628
Cat # LS055800
20 µg, 100 µg

SCN3B Overview

Facts about Sodium channel subunit beta-3.

SCN3B 3D structure. Source: alphafold

Sodium channel subunit beta-3 (SCN3B)

Modulates channel gating kinetics. Causes unique persistent sodium currents.

Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and keep these channels at the nodes in mature myelinated axons (By similarity).

Gene Information

Human
Gene Name:	SCN3B
Uniprot:	Q9NY72
Entrez:	55800

Family

Belongs to:

sodium channel auxiliary subunit SCN3B (TC 8.A.17) family

Alternative Names

HSA243396; KIAA1158; SCNB3; sodium channel subunit beta-3; sodium channel, voltage-gated, type III, beta; voltage-gated sodium channel beta-3 subunit

Molecular Weight

Mass (kDA):
24.702 kDA

Genomic Context


Human

Location:	11q24.1
Sequence:	11; NC_000011.10 (123629187..123654607, complement)

Tissue Specificity

Expressed in the atrium.

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

Cardiac Arrhythmia
Brugada Syndrome (disorder)
Cardiac Fibrillation
Tachycardia, Ventricular
Sudden Infant Death Syndrome
Ventricular Fibrillation
Atrial Fibrillation
Sclerosis
Malignant Neoplasms
Long Qt Syndrome
Malignant Paraganglionic Neoplasm
Epilepsy

Heart Diseases
Neonatal Maladjustment Syndrome
Primary Lateral Sclerosis
Malignant Neoplasm Of Breast
Epilepsy, Generalized
Amyotrophic Lateral Sclerosis

Interacting Proteins

ARV1

Pathways

Pathogenesis
Transport
Cell Adhesion
Cardiac Conduction

PTMs

Biotinylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SCN3B

References

PMID: 10688874 by Morgan K., et al. Beta3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics.

PMID: 20031595 by Hu D., et al. A mutation in the beta-3 subunit of the cardiac sodium channel associated with Brugada ECG phenotype.