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- Table of Contents
Protein scribble homolog Antibodies
AND SCRIB ELISA kits, Protein scribble homolog Proteins
Many biological assays use antibodies to detect Protein scribble homolog, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein scribble homolog in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein scribble homolog antibodies...
Designing a Western blot for Protein scribble homolog? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SCRIB Western Blot GuideSCRIB Infographic by Boster Bio
All SCRIB Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01653-4
100 μg/vial
Cat # A01653-4
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A01651
100 μg/vial
Cat # A01651
100 μg/vial
Human, Mouse
ELISA, Flow Cytometry, IF, WB
$370
Cat # A01652-2
100 μg/vial
Cat # A01652-2
100 μg/vial
Fruit fly
IF, WB
$470
Cat # DZ41939
200 μl/vial
Cat # DZ41939
200 μl/vial
SCRIB Overview
Facts about Protein scribble homolog.
Protein scribble homolog (SCRIB)
Scaffold protein involved in various areas of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most likely functions in the creation of apico-basal cell polarity.
May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for example through acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling.
Gene Information
| Human | |
|---|---|
| Gene Name: | SCRIB |
| Uniprot: | Q14160 |
| Entrez: | 23513 |
Family
| Belongs to: |
|---|
| LAP (LRR and PDZ) protein family |
Alternative Names
protein scribble homolog; CRIB1; SCRB1; SCRIB1; scribbled homolog (Drosophila); Vartul
Molecular Weight
Mass (kDA):
174.885 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q24.3 |
| Sequence: | 8; NC_000008.11 (143790925..143815773, complement) |
Tissue Specificity
Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).
Subcellular Localizations
Cell membrane; Peripheral membrane protein. Cell junction, adherens junction. Cell projection, lamellipodium. Cytoplasm. Cell junction, synapse, postsynapse. Cell junction, synapse, presynapse. Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity.
Diseases
- Neoplasms
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Tissue Adhesions
- Cell Invasion
- Mammary Neoplasms
- Malignant Paraganglionic Neoplasm
- Tumor Progression
- Malignant Neoplasm Of Breast
- Carcinoma
- Neoplasm Metastasis
- Common Wart
Interacting Proteins
- ADAM22
- ADRA1D
- APC
- ARHGEF7
- ATP2B1
- ATP2B2
- CRHR1
- CTNND2
- CYSLTR2
- DNM1L
Pathways
- Localization
- Cell Proliferation
- Cell Migration
- Cell Growth
- Cell Adhesion
- Cell Division
- Cell-cell Adhesion
- Neural Tube Closure
- Tube Closure
- Cell Cycle
- Wound Healing
- Cell Death
- Receptor Recycling
PTMs
- Phosphorylation
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SCRIB
bosterbio.com/bosterbio-gene-info-cards/SCRIB
References
PMID: 15649318 by Petit M.M.R., et al. The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus.
PMID: 15806148 by Navarro C., et al. Junctional recruitment of mammalian Scribble relies on E-cadherin engagement.