Syndecan-4 Antibodies

Syndecan-4 (SDC4)

Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).

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Gene Information

Human
Gene Name:	SDC4
Uniprot:	P31431
Entrez:	6385

Family

Belongs to:
syndecan proteoglycan family

Alternative Names

Amphiglycan; MGC22217; Ryudocan core protein; Ryudocan; SDC4; SYND4ryudocan amphiglycan; syndecan 4 (amphiglycan, ryudocan); syndecan 4; syndecan proteoglycan 4; Syndecan4; Syndecan-4

Molecular Weight

Mass (kDA):
21.642 kDA

Genomic Context

Human
Location:	20q13.12
Sequence:	20; NC_000020.11 (45325288..45348424, complement)

Tissue Specificity

Expressed in epithelial and fibroblastic cells.

Subcellular Localizations

[Isoform 1]: Membrane; Single-pass type I membrane protein. Secreted. Shedding of the ectodomain produces a soluble form.; [Isoform 2]: Secreted.

Diseases

• Tissue Adhesions
• Neoplasms
• Malignant Neoplasms
• Inflammation
• Carcinoma
• Cell Invasion
• Tumor Angiogenesis
• Fibrosis
• Neoplasm Metastasis
• Malignant Neoplasm Of Breast
• Neoplasm Invasiveness
• Pathologic Neovascularization

• Malignant Paraganglionic Neoplasm
• Kidney Diseases
• Hyperplasia
• Mammary Neoplasms
• Brain Neoplasms
• Cholangiocarcinoma
• Malignant Squamous Cell Neoplasm

Interacting Proteins

• PRKCA
• SDC2
• SDC3
• SGTA

Pathways

• Cell Adhesion
• Cell Migration
• Cell Proliferation
• Wound Healing
• Localization
• Angiogenesis
• Sulfation
• Pathogenesis
• Cell Growth
• Cell Motility
• Cell-matrix Adhesion
• Chemotaxis
• Regeneration

• Cell Cycle
• Tube Formation
• Endocytosis
• Locomotion
• Rna Interference
• Cytoskeleton Organization
• Transport

PTMs

• Phosphorylation
• Cleavage
• Biotinylation
• Acetylation
• Sulphation

• Glycosylation
• Dephosphorylation
• Methylation
• Oxidation
• Gpi Anchoring

• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SDC4

Boster Bio - Best Uses Of The SDC4 Marker

Boster Bio offers many antibodies including the Anti-Syndecan4/SDC4 marker. We'll be taking a closer look at the antibody, and then discussing ways to maximize its potential benefits. We'll also discuss the Anti-Bax (S4) Antibody and the Anti-KHDRBS2 antibody. These three antibodies are the basis of numerous other biomarkers, therefore an understanding of their application is essential to make the most of these three antibodies.

Boster Bio's Anti-Syndecan 4/SDC4 marker

Syndecan-4, also known as SDC4 is a transmembrane heparan sulfate proteoglycan that has a molecular weight of 20 kDa. It is the most studied type of plasma membrane proteoglycan, and it plays a role in cell signaling, binding and cytoskeletal organization. Syndecans are usually found on fibroblasts . They function as integral membrane proteins, playing a role in cell proliferation, cell movement and integrin-mediated interactions. They also play a role in cell migration. Mechanical stress and TGF beta2 boost their expression.

Syndecan-4 is one of the major Syndecans in human primary endothelial cells. It is involved in wound healing and is modulated by various inflammation-related stimuli. Its structure provides insights into the dynamics of proteins and ligand conformation. In this way it can be used to determine various diseases and their treatments. Boster Bio can sell it.

PAR-3 and Syndecan-4 play a significant role in regulators of polarized cells migration. Their interaction with PAR-3 is dependent on the EFYA sequence of the Syndecan-4 tail. This interaction provides new insights into the mechanism of cell movement. Because Syndecan-4 and PAR-3 act as oligomers they can independently bind to a variety of proteins, including integrin FAK and Tiam1.

Anti-Syndecan 4/ SDC4 (SDC4) is a great marker to detect syndecans within various cells. This antibody binds to syndecan-4 cytoplasmic domains to identify astrocytes. It is a good tool to identify many diseases and is highly specific for syndecans found in various kinds of cells and tissues.

Syntenin connects to the EFYA sequence in Syndecan-4 and is an excellent controller for experiments. It can also be useful in precipitation assays since Syntenin does not compete with PAR-3. This makes the Syntenin/SDC4 marker the best tool for this type of research. Although it's not the most effective antibody however, it is one of the best available.

Human Syndecan-4 is a 198-amino-acid protein that has an 18-amino amino acid signal sequence and a extracellular domain that contains 127 amino acids. It also has three Ser-Gly consensus sequences. Its extracellular domain shares 79% of the same DNA sequence as mouse, rat, and human ECD. In addition, human Syndecan-4 contains twenty-80 disaccharides per side chain. It's therefore twenty-kDa. It also has a transmembrane domain that allows for non-covalent homodimerization.

Boster Bio's AntiBax (S4) Antibody

In addition to being clinically effective, the Anti-Bax (S4) antibody is approved as safe and effective by the European Union Committee for Medicinal Products for Human Use. It is in compliance with European Union requirements for human-use vaccines. You can purchase it at many online retailers. Below is more information on Boster Bio's Anti-Bax S4 Antibody.

Boster Bio's Anti-KHDRBS2 Antibody

This antibody is part Picoband(tm) and has been tested in WB as well as IHC. Boster Bio Anti-Syndecan 4 reacts with Human, Mouse, and Rat. A validation panel made up of known positive and negative samples determined its specificity and affinity. Boster also rewards its first reviewers with product credits. Boster also rewards scientists across the globe for their hard work.