Succinate dehydrogenase assembly factor 4, mitochondrial (Sdhaf4)

Plays an important role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) which is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit Sdha in its FAD-bound form, blocking the creation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit Sdhb to the SDH catalytic dimer (By similarity).

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