This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
SEC63 Antibodies
AND SEC63 ELISA kits, SEC63 Proteins
Many biological assays use antibodies to detect SEC63, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SEC63 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SEC63 antibodies...
Designing a Western blot for SEC63? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SEC63 Western Blot GuideDesigning an IHC experiment for SEC63? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SEC63 IHC GuideSEC63 Infographic by Boster Bio
All SEC63 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A04852-1
100 μg/vial
Cat # A04852-1
100 μg/vial
SEC63 Overview
Facts about Translocation protein SEC63 homolog.
Translocation protein SEC63 homolog (SEC63)
Mediates cotranslational and post-translational transport of specific precursor polypeptides across endoplasmic reticulum (ER) (PubMed:22375059, PubMed:29719251). Proposed to play an auxiliary role in recognition of precursors with brief and apolar signal peptides.
May collaborate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins to the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation into the ER lumen (PubMed:29719251). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the principal cilia (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | SEC63 |
| Uniprot: | Q9UGP8 |
| Entrez: | 11231 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
PRO2507; SEC63 homolog (S. cerevisiae); SEC63LERdj2; SEC63-like (S. cerevisiae); translocation protein SEC63 homolog
Molecular Weight
Mass (kDA):
87.997 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q21 |
| Sequence: | 6; NC_000006.12 (107867756..107958208, complement) |
Tissue Specificity
Widely expressed, with high levels in the liver.
Subcellular Localizations
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Diseases
- Liver Diseases
- Polycystic Liver Disease
- Neoplasms
- Malignant Neoplasms
- Microsatellite Instability
- Polycystic Kidney, Autosomal Dominant
- Polycystic Kidney Diseases
- Kidney Diseases
- Mutation, Out-of-frame
- Germline Mutation Abnormality
- Physiological Stress
- Colorectal Neoplasms
Interacting Proteins
- Nxn
Pathways
- Transport
- Protein Transport
- Localization
- Secretory Pathway
- Glycosylation
- Cell Growth
- Protein Import
- Mating
- Membrane Fusion
- Protein Folding
- Secretion
- Protein Processing
- Protein Secretion
PTMs
- Glycosylation
- Ubiquitination
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SEC63
bosterbio.com/bosterbio-gene-info-cards/SEC63
References
PMID: 10543453 by Skowronek M.H., et al. Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog.
PMID: 10799540 by Meyer H.-A., et al. Mammalian Sec61 is associated with Sec62 and Sec63.