Selenoprotein N Antibodies

AND SELENON ELISA kits, Selenoprotein N Proteins

Many biological assays use antibodies to detect Selenoprotein N, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Selenoprotein N in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Selenoprotein N antibodies...

We validate the specificity of these antibodies to Selenoprotein N by testing them on tissues known to express SELENON positively and negatively. Browse below to find the SELENON antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SELENON Infographic by Boster Bio

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Anti-SELENON Antibody Picoband®

1 Citations

Western blot analysis of SELENON using anti-SELENON antibody (A31971-1)

Flow Cytometry analysis of HEL cells using anti-SELENON antibody (A31971-1)

Human

ELISA, Flow Cytometry, WB

$370
Cat # A31971-1
100 µg/vial

SELENON Overview

Facts about Selenoprotein N.

Selenoprotein N (SELENON)

Isoform 2: Plays an essential role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage.

Within the ER, ERO1A activity raises the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus results in cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (- SH), thus restoring ATP2A2 action (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) action: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization needed for normal muscle development and differentiation (PubMed:19557870, PubMed:18713863).

Gene Information

Human
Gene Name:	SELENON
Uniprot:	Q9NZV5
Entrez:	57190

Family

Belongs to:

No superfamily

Alternative Names

Selenoprotein N

Molecular Weight

Mass (kDA):
65.813 kDA

Genomic Context


Human

Location:	1p36.11
Sequence:	1; NC_000001.11 (25800193..25818221)

Tissue Specificity

Isoform 1 and isoform 2 are expressed in skeletal muscle, brain, lung and placenta. Isoform 2 is also expressed in heart, diaphragm and stomach.

Subcellular Localizations

[Isoform 2]: Endoplasmic reticulum membrane.

Interacting Proteins

NCK1

PTMs

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SELENON

References

PMID: 11528383 by Moghadaszadeh B., et al. Mutations in SEPN1 cause congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome.

PMID: 10608886 by Lescure A., et al. Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif.