SENP3 Antibodies

AND SENP3 ELISA kits, SENP3 Proteins

Many biological assays use antibodies to detect SENP3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SENP3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SENP3 antibodies...

We validate the specificity of these antibodies to SENP3 by testing them on tissues known to express SENP3 positively and negatively. Browse below to find the SENP3 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for SENP3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the SENP3 Western Blot Guide

Designing an IHC experiment for SENP3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the SENP3 IHC Guide

SENP3 Infographic by Boster Bio

All SENP3 Products

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Product

Figures

Specificity

Applications

Price

Anti-SENP3 (Y24) Antibody

Western blot (WB) analysis of SENP3 (Y24) polyclonal antibody at 1:500 dilution
Lane1:C6 whole cell lysate(40ug)
Lane2:NIH-3T3 whole cell lysate(40ug)
Lane3:Hela whole cell lysate(40ug)
Lane4:COS-7 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of SENP3 (Y24) pAb in paraffin-embedded human breast carcinoma tissue at 1:100

Human, Mouse, Rat

IHC, WB

$405
Cat # A04474Y24
100ul

SENP3 (NM_015670) Human Over-expression Lysate

Human

$628
Cat # LS026168
20 µg, 100 µg

Anti-SENP3 Antibody

Human, Mouse, Rat

IP, IHC, WB

$370
Cat # A04474-1
100 μl/vial

SENP3 Overview

Facts about Sentrin-specific protease 3.

SENP3 3D structure. Source: alphafold

Sentrin-specific protease 3 (SENP3)

Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8.

Redox sensor which, when redistributed into nucleoplasm, can act as an effector to boost HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1.

Gene Information

Human
Gene Name:	SENP3
Uniprot:	Q9H4L4
Entrez:	26168

Family

Belongs to:

peptidase C48 family

Alternative Names

DKFZP586K0919; DKFZp762A152; EC 3.4.22; EC 3.4.22.-; sentrin/SUMO-specific protease 3; Sentrin/SUMO-specific protease SENP3; sentrin-specific protease 3; SMT3IP1; SSP3DKFZp586K0919; SUMO1/sentrin/SMT3 specific peptidase 3; SUMO1/sentrin/SMT3 specific protease 3; SUMO-1-specific protease 3; SUSP3

Molecular Weight

Mass (kDA):
65.01 kDA

Genomic Context


Human

Location:	17p13.1
Sequence:	17; NC_000017.11 (7561919..7571969)

Subcellular Localizations

Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm. Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress (PubMed:19680224). Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity).

Diseases

Malignant Neoplasms
Adenocarcinoma
Neoplasms
Pancreatic Ductal Adenocarcinoma
Spinal Cord Injuries
Colonic Neoplasms
Hematopoietic Neoplasms
Hypoxia
Trauma, Nervous System
Inflammatory Response
Carcinogenesis
Carcinoma, Pancreatic Ductal
Nervousness

Adenocarcinoma Of Colon
Acute Promyelocytic Leukemia
Pancreatic Neoplasm
Leukemia
Inflammation
Peritonitis
Malignant Neoplasm Of Pancreas

Interacting Proteins

NPM1
PELP1
TEX10
UBC
WDR18

Pathways

Localization
Ribosome Biogenesis
Cell Proliferation
Conjugation
Cell Cycle
Cell Growth
Mitosis
Proteolysis
Nuclear Export
Cell Cycle Arrest
Inflammatory Response
Cytokinesis
Methylation

Response To Oxidative Stress
Histone H3 Acetylation
Cell Death
Regulation Of Cell Proliferation
Post-translational Protein Modification
Spindle Assembly Checkpoint
Interphase

PTMs

Sumoylation
Ubiquitination
Phosphorylation

Acetylation
Cleavage
Methylation

Ribosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SENP3

References

PMID: 10806345 by Yeh E.T.H., et al. Ubiquitin-like proteins: new wines in new bottles.

PMID: 15960975 by Dou Y., et al. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.