Sentrin-specific protease 3 (SENP3)

Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8.

Redox sensor which, when redistributed into nucleoplasm, can act as an effector to boost HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1.