- Table of Contents
We validate the specificity of these antibodies to Septin-2 by testing them on tissues known to express SEPTIN2 positively and negatively. Browse below to find the SEPTIN2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.
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Facts about Septin-2.
Filament-forming cytoskeletal GTPase.Types a filamentous arrangement with SEPT12, SEPT6, SEPT2 and likely SEPT4 at the sperm annulus that's required for the structural integrity and motility of the sperm tail through postmeiotic distinction (PubMed:25588830).
Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin.
|TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily|
|Sequence:||2; NC_000002.12 (241315187..241354027)|
Widely expressed. Up-regulated in liver cancer.
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody. Cytoplasm, cell cortex. Cell projection, cilium membrane. Cell projection, cilium, flagellum. In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. During bacterial infection, displays a collar shape structure next to actin at the pole of invading