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- Table of Contents
Sestrin-2 Antibodies
AND SESN2 ELISA kits, Sestrin-2 Proteins
Many biological assays use antibodies to detect Sestrin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sestrin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sestrin-2 antibodies...
Designing a Western blot for Sestrin-2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SESN2 Western Blot GuideSESN2 Infographic by Boster Bio
All SESN2 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A02558-1
100 μg/vial
Cat # A02558-1
100 μg/vial
Human, Mouse, Rat
ELISA, IP, IF, WB
$146
Cat # M02558-1
20μL, 40μL, 100μL, 200μL
Cat # M02558-1
20μL, 40μL, 100μL, 200μL
SESN2 Overview
Facts about Sestrin-2.
Sestrin-2 (SESN2)
Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190).
Binding of leucine into SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses.
Gene Information
| Human | |
|---|---|
| Gene Name: | SESN2 |
| Uniprot: | P58004 |
| Entrez: | 83667 |
Family
| Belongs to: |
|---|
| sestrin family |
Alternative Names
DKFZp761M0212; DKFZp761M02121; Hi95; HI95sestrin-2; SES2; SEST2hypoxia induced gene 95; sestrin 2
Molecular Weight
Mass (kDA):
54.494 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p35.3 |
| Sequence: | 1; NC_000001.11 (28259452..28282491) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Hypoxia
- Mammary Neoplasms
- Genomic Instability
- Anoxia
- Cell Transformation, Neoplastic
- Obesity
- Hereditary Hemorrhagic Telangiectasia
- Melanoma
- Malignant Neoplasm Of Breast
- Ataxia
Interacting Proteins
- KEAP1
- MIOS
- RBX1
- Rbx1
- SQSTM1
- Ulk1
- WDR24
Pathways
- Cell Cycle
- Cell Growth
- Aging
- Cell Proliferation
- Autophagy
- Cell Death
- Rna Interference
- Cell Cycle Arrest
- Sensitization
- Energy Homeostasis
- Pathogenesis
- Transport
- Programmed Cell Death
PTMs
- Phosphorylation
- Reduction
- Cleavage
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SESN2
bosterbio.com/bosterbio-gene-info-cards/SESN2
References
PMID: 12203114 by Budanov A.V., et al. Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability.
PMID: 12607115 by Peeters H., et al. PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse.