Protein SETSIP (SETSIP)

Plays a role as a transcriptional activator involved in the first phase of somatic cell reprogramming. Promotes the differentiation of protein-induced pluripotent stem (PiPS) cells to endothelial cells and the formation of vascular-like tubes (in vitro).

Involved from the transcription induction of vascular endothelial-cadherin (VE-cadherin) expression. Associates to the VE-cadherin gene promoter.