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- Table of Contents
SF3B1 Antibodies
AND SF3B1 ELISA kits, SF3B1 Proteins
Many biological assays use antibodies to detect SF3B1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SF3B1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SF3B1 antibodies...
Designing a Western blot for SF3B1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SF3B1 Western Blot GuideDesigning an IHC experiment for SF3B1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SF3B1 IHC GuideSF3B1 Infographic by Boster Bio
All SF3B1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00507-1
100 μl/vial
Cat # M00507-1
100 μl/vial
SF3B1 Overview
Facts about Splicing factor 3B subunit 1.
Splicing factor 3B subunit 1 (SF3B1)
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA.
Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex (PubMed:10882114).
Gene Information
| Human | |
|---|---|
| Gene Name: | SF3B1 |
| Uniprot: | O75533 |
| Entrez: | 23451 |
Family
| Belongs to: |
|---|
| SF3B1 family |
Alternative Names
Hsh155; pre-mRNA processing 10; pre-mRNA splicing factor SF3b, 155 kDa subunit; Pre-mRNA-splicing factor SF3b 155 kDa subunit; Prp10; PRPF10; SAP 155; SAP155splicing factor 3b, subunit 1, 155kD; SF3B155; SF3b155PRP10; spliceosome associated protein 155; Spliceosome-associated protein 155; splicing factor 3B subunit 1; splicing factor 3b, subunit 1, 155kDa
Molecular Weight
Mass (kDA):
145.83 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q33.1 |
| Sequence: | 2; NC_000002.12 (197389784..197435093, complement) |
Subcellular Localizations
Nucleus. Nucleus speckle. During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm.
Diseases
- Dysmyelopoietic Syndromes
- Leukemia
- Malignant Neoplasms
- Neoplasms
- Chronic Lymphocytic Leukemia
- Lymphoid Leukemia
- Myeloid Leukemia
- Leukemia, Myelocytic, Acute
- Anemia
- Refractory Anemia With Ringed Sideroblasts
- Refractory Anemias
- Dysplasia
Interacting Proteins
- RBM17
- SF3B6
Pathways
- Pathogenesis
- Mrna Splicing
- Rna Splicing
- Spermatogenesis
- Cell Division
- Fermentation
- Cell Cycle
- Chromatin Modification
- Cell Proliferation
- Localization
- Rna Interference
- Hyperphosphorylation
- Proteolysis
PTMs
- Phosphorylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SF3B1
bosterbio.com/bosterbio-gene-info-cards/SF3B1
References
PMID: 9585501 by Wang C., et al. Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis.
PMID: 10882114 by Das R., et al. Functional association of U2 snRNP with the ATP-independent spliceosomal complex E.