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- Table of Contents
Facts about SH3 domain-containing kinase-binding protein 1.
Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity).
Human | |
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Gene Name: | SH3KBP1 |
Uniprot: | Q96B97 |
Entrez: | 30011 |
Belongs to: |
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No superfamily |
C-Cbl-Interacting Protein; CD2-binding protein 3; CD2BP3; CIN85; CIN85Cbl-interacting protein of 85 kDa; GIG10; HSB1; HSB-1; Human Src family kinase-binding protein 1; MIG18; migration-inducing gene 18; SH3 domain-containing kinase-binding protein 1; SH3-domain kinase binding protein 1; SH3KBP1; Src family kinase-binding protein 1; src-related kinase binding protein-1
Mass (kDA):
73.126 kDA
Human | |
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Location: | Xp22.12 |
Sequence: | X; NC_000023.11 (19533965..19887600, complement) |
Ubiquitously expressed. Also expressed in some cancer cell lines.
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Cell junction, focal adhesion. Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes. Translocation to EGFR containing vesicles upon EGF stimulation is inhibited in the presence of SH3KBP1 (By similarity). Colocalizes with ZFP36 in the cytoplasm (PubMed:20221403).
The SH3KBP1 Marker is an anti-SH3K1 antibody. It is a unique protein that is present in many cells in the body. In addition to the anti-SH3K1 antibody, Boster Bio also offers a variety of secondary antibodies and ELISA kits. In this article, we discuss the best uses of the SH3KBP1 marker.
The Boster Bio Anti-SH3K1SH3KBP1 Marker is a human antibody that reacts to SH3 domain-containing kinase. The antibody is made from a peptide derived from the human SH3KBP1 gene. The cost of blocking peptides varies according to the length of immunogen. The price of this product depends on the amount of immunogen used and the size of the peptide.
SH3KBP1 is a tumor-specific marker found on a variety of human cancers. The marker can detect mutations in several genes including BRAF (V600E), NRAS (Q61R), HRAS (T890N), OTUD4-ALK (T909I), ANKMY1 (N3021), DNAh20 (G9D), and FCGRT (P40A) gene.
The SH3KBP1 marker is a widely expressed protein in human ovarian cancer cells. Researchers studying this protein will be able to detect it by using Boster Bio's research ELISA kits. These kits offer high sensitivity and can detect the marker with picogram-level sensitivity. These ELISA kits are available through BeNeLux distributor Sanbio.
The reagents for the SH3KBP1 marker are manufactured by CUSABIO under a quality control process. These reagents are validated for multiple applications and come with solid technical support. Sanbio also offers custom services and BeNeLux delivery. They are available worldwide. Contact Sanbio for more information. We are happy to assist you in your research.
PMID: 10679202 by Take H., et al. Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl.
PMID: 12618476 by Tibaldi E.V., et al. CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment but elicit divergent functional activities.