SH3 domain-containing kinase-binding protein 1 (SH3KBP1)

Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, such as EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and so the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2.

Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity).