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- Table of Contents
Facts about SHC-transforming protein 4.
.
Mouse | |
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Gene Name: | Shc4 |
Uniprot: | Q6S5L9 |
Entrez: | 271849 |
Belongs to: |
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No superfamily |
hShcD; MGC34023; Rai-like protein; RaLPSH2 domain protein C4; SHC (Src homology 2 domain containing) family, member 4; SHCD; SHC-transforming protein 4; SHC-transforming protein D; Src homology 2 domain-containing-transforming protein C4
Mass (kDA):
68.519 kDA
Mouse | |
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Location: | 2|2 F1 |
Sequence: | 2; |
Expressed in both brain and skeletal muscle; widely expressed in brain namely olfactory bulb, cortex, hippocampus, striatum, thalamus, and brain stem (at protein level). Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential.
PMID: 17409413 by Fagiani E., et al. RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas.
PMID: 17452444 by Jones N., et al. Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase.