Shieldin complex subunit 1 (Shld1)

Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the intricate functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection.

Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. .