SHLD2 Antibodies

AND SHLD2 ELISA kits, SHLD2 Proteins

Many biological assays use antibodies to detect SHLD2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SHLD2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SHLD2 antibodies...

We validate the specificity of these antibodies to SHLD2 by testing them on tissues known to express SHLD2 positively and negatively. Browse below to find the SHLD2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SHLD2 Infographic by Boster Bio

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FAM35A (NM_019054) Human Over-expression Lysate

Human

$628
Cat # LS054537
20 µg, 100 µg

SHLD2 Overview

Facts about Shieldin complex subunit 2.

SHLD2 3D structure. Source: alphafold

Shieldin complex subunit 2 (SHLD2)

Component of the shieldin complex, which has an essential role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the intricate functions downstream of TP53BP1 to market non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392).

Mediates various NHEJ- dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). .

Gene Information

Human
Gene Name:	SHLD2
Uniprot:	Q86V20
Entrez:	54537

Family

Belongs to:

SHLD2 family

Alternative Names

Shieldin complex subunit 2

Molecular Weight

Mass (kDA):
93.705 kDA

Genomic Context


Human

Location:	10q23.2
Sequence:	10; NC_000010.11 (87094478..87191468)

Subcellular Localizations

Nucleus. Chromosome. Localizes to nuclear foci in response to DNA damage.

Interacting Proteins

SHLD1
TP53BP1

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SHLD2

References

PMID: 29656893 by Gupta R., et al. DNA repair network analysis reveals shieldin as a key regulator of NHEJ and PARP inhibitor sensitivity.

PMID: 29789392 by Tomida J., et al. FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1-defective cells.