SHLD3 Antibodies

AND SHLD3 ELISA kits, SHLD3 Proteins

Many biological assays use antibodies to detect SHLD3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SHLD3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SHLD3 antibodies...

We validate the specificity of these antibodies to SHLD3 by testing them on tissues known to express SHLD3 positively and negatively. Browse below to find the SHLD3 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SHLD3 Infographic by Boster Bio

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SHLD3 Overview

Facts about Shieldin complex subunit 3.

SHLD3 3D structure. Source: alphafold

Shieldin complex subunit 3 (SHLD3)

Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection.

Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. .

Gene Information

Human
Gene Name:	SHLD3
Uniprot:	Q6ZNX1
Entrez:	112441434

Family

Belongs to:

No superfamily

Alternative Names

Shieldin complex subunit 3

Molecular Weight

Mass (kDA):
28.842 kDA

Genomic Context


Human

Location:	5q12.3
Sequence:	5; NC_000005.10 (65625027..65630928)

Subcellular Localizations

Chromosome. Recruited to sites of chromosomal double-stranded breaks during G1 and S phase of the cell cycle.

Interacting Proteins

MAD2L2

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SHLD3

References

PMID: 29656893 by Gupta R., et al. DNA repair network analysis reveals shieldin as a key regulator of NHEJ and PARP inhibitor sensitivity.