E3 ubiquitin-protein ligase SHPRH (SHPRH)

E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the creation of non-canonical poly-ubiquitin chains linked through'Lys-63'.

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