Shootin-1 (SHTN1)

Involved in the creation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium expansion and axon outgrowth.

Plays a role in cytoskeletal organization by controlling the subcellular localization of phosphoinositide 3-kinase (PI3K) activity in the axonal growth cone. Plays also a role in regenerative neurite outgrowth.