Siah1b Antibodies

AND Siah1b ELISA kits, Siah1b Proteins

Many biological assays use antibodies to detect Siah1b, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Siah1b in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Siah1b antibodies...

We validate the specificity of these antibodies to Siah1b by testing them on tissues known to express Siah1b positively and negatively. Browse below to find the Siah1b antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Siah1b Infographic by Boster Bio

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Siah1b Overview

Facts about E3 ubiquitin-protein ligase SIAH1B.

Siah1b 3D structure. Source: alphafold

E3 ubiquitin-protein ligase SIAH1B (Siah1b)

E3 ubiquitin ligases take ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by working as the essential RING domain subunit of larger E3 complexes.

Confers constitutive instability to HIPK2 through proteasomal degradation. Probably activates the ubiquitin- mediated degradation of many substrates.

Gene Information

Mouse
Gene Name:	Siah1b
Uniprot:	Q06985
Entrez:	20438

Family

Belongs to:

SINA (Seven in absentia) family

Alternative Names

E3 ubiquitin-protein ligase SIAH1B

Molecular Weight

Mass (kDA):
31.122 kDA

Genomic Context


Mouse

Location:	X F5\|X 76.11 cM
Sequence:	X;

Tissue Specificity

Widely expressed at low level in embryos and adults. Due to the high similarity between SIAH1A and SIAH1B, it is difficult to distinguish its own tissue specificity. Overexpressed in endothelial cells of adult lung.

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Siah1b

References

PMID: 8404535 by Della N.G., et al. Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina).

PMID: 8632996 by Amson R.B., et al. Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: activation of the vertebrate homologue of the Drosophila seven in absentia gene.