Sigirr Antibodies

AND Sigirr ELISA kits, Sigirr Proteins

Many biological assays use antibodies to detect Sigirr, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sigirr in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sigirr antibodies...

We validate the specificity of these antibodies to Sigirr by testing them on tissues known to express Sigirr positively and negatively. Browse below to find the Sigirr antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Sigirr? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the SIGIRR IHC Guide

Sigirr Infographic by Boster Bio

All Sigirr Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-SIGIRR Antibody Picoband®

Western blot analysis of SIGIRR using anti-SIGIRR antibody (A03373-2)

IHC analysis of SIGIRR using anti-SIGIRR antibody (A03373-2)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A03373-2
100 μg/vial

SIGIRR (NM_001135054) Human Over-expression Lysate

SIGIRR Human Over-expression Lysates NM_001135053

Human

$628
Cat # LS059307
20 µg, 100 µg

SIGIRR (NM_021805) Human Recombinant Protein

Coomassie blue staining of purified SIGIRR protein

$1249
Cat # PROTQ6IA17
20 µg

Anti-SIGIRR Antibody

Western blot analysis of SIGIRR expression in (A) A549 and (B) MCF7 cell lysate with SIGIRR antibody at 1 μg/ml

Immunocytochemistry of SIGIRR in A549 cells with SIGIRR antibody at 10 μg/mL

Human, Mouse

ELISA, ICC, WB

$481
Cat # A03373
0.1 mg

Sigirr Overview

Facts about Single Ig IL-1-related receptor.

Single Ig IL-1-related receptor (Sigirr)

Acts as a negative regulator of this Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4.

Throughout its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity). .

Gene Information

Mouse
Gene Name:	Sigirr
Uniprot:	Q9JLZ8
Entrez:	24058

Family

Belongs to:

interleukin-1 receptor family

Alternative Names

IL-1R8; SIGIRR; single Ig IL-1-related receptor; Single Ig IL-1R-related molecule; single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; single immunoglobulin domain IL1R1 related; Single immunoglobulin domain-containing IL1R-related protein; TIR8; TIR8MGC110992; Toll/interleukin-1 receptor 8

Molecular Weight

Mass (kDA):
46.159 kDA

Genomic Context


Mouse

Location:	7\|7 F5
Sequence:	7;

Tissue Specificity

Expressed at high levels in kidney, and at moderate levels in colon, small intestine, lung, spleen and liver. Not expressed in brain and muscle. Expressed at high levels in epithelial cells, at moderate levels in splenocytes, and at low or undetectable levels in fibroblasts or endothelial cells. Expressed in mucosal and dendritic cells.

Diseases

Inflammation
Inflammatory Response
Lupus Erythematosus, Systemic
Autoimmunity
Malignant Neoplasms
Innate Immune Response
Colitis
Neoplasms
Pseudomonas Infections
Autoimmune Reaction
Nephritis
Arthritis
Asthma

Acute Lung Injury
Nerve Degeneration
Keratitis
Systemic Infection
Corneal Diseases
Inflammatory Bowel Diseases
Autoimmune Diseases

Pathways

Immune Response
Inflammatory Response
Pathogenesis
Cell Proliferation
Adaptive Immune Response
Cell Activation
Cytokine Production
Innate Immune Response
Secretion
Response To Lipopolysaccharide
Gene Silencing
Cytokine Secretion
Tumor Necrosis Factor Production

Hypersensitivity
Virulence
Interleukin-10 Production
Anaphase
Reverse Transcription
Phagocytosis
Tissue Remodeling

PTMs

Phosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Sigirr

References

PMID: 14993616 by Garlanda C., et al. Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family.

PMID: 10346978 by Thomassen E., et al. Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily.