Single Ig IL-1-related receptor (Sigirr)

Acts as a negative regulator of this Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4.

Throughout its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity). .