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- Table of Contents
Facts about Sialic acid-binding Ig-like lectin 16.
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Human | |
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Gene Name: | SIGLEC16 |
Uniprot: | A6NMB1 |
Entrez: | 400709 |
Belongs to: |
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immunoglobulin superfamily |
Sialic acid-binding Ig-like lectin 16
Mass (kDA):
52.992 kDA
Human | |
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Location: | 19q13.33 |
Sequence: | 19; NC_000019.10 (49969664..49975814) |
Expressed in bone marrow, fetal brain, fetal liver, lung and salivary gland. Detected in brain, macrophage, cancerous esophagus and lung at protein level.
Membrane; Single-pass type I membrane protein.
PMID: 11986327 by Angata T., et al. Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia.
PMID: 18629938 by Cao H., et al. SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans.