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- Table of Contents
SIRT5 Antibodies
AND SIRT5 ELISA kits, SIRT5 Proteins
Many biological assays use antibodies to detect SIRT5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SIRT5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SIRT5 antibodies...
Designing a Western blot for SIRT5? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SIRT5 Western Blot GuideSIRT5 Infographic by Boster Bio
All SIRT5 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A02395-3
100 μg/vial
Cat # A02395-3
100 μg/vial
SIRT5 Overview
Facts about NAD-dependent protein deacylase sirtuin-5, mitochondrial.
NAD-dependent protein deacylase sirtuin-5, mitochondrial (SIRT5)
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469). Activates CPS1 and contributes to the regulation of blood glucose levels during prolonged fasting: functions by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693).
Activates SOD1 by mediating its desuccinylation, resulting in decreased reactive oxygen species (PubMed:24140062). Activates SHMT2 by mediating its desuccinylation (PubMed:29180469).
Gene Information
| Human | |
|---|---|
| Gene Name: | SIRT5 |
| Uniprot: | Q9NXA8 |
| Entrez: | 23408 |
Family
| Belongs to: |
|---|
| sirtuin family |
Alternative Names
EC 3.5.1; EC 3.5.1.-; FLJ36950; NAD-dependent deacetylase sirtuin-5; silent mating type information regulation 2, S.cerevisiae, homolog 5; SIR2L5; sir2-like 5; SIR2-like protein 5; SIRT5; sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae); sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 5; Sirtuin 5; sirtuin type 5
Molecular Weight
Mass (kDA):
33.881 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p23 |
| Sequence: | 6; NC_000006.12 (13574217..13615158) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Mitochondrion matrix. Mitochondrion intermembrane space. Cytoplasm, cytosol. Nucleus. Mainly mitochondrial. Also present extramitochondrially, with a fraction present in the cytosol and very small amounts also detected in the nucleus.; [Isoform 1]: Cytoplasm. Mitochondrion.; [Isoform 2]: Mitochondrion.
Diseases
- Metabolic Diseases
- Malignant Neoplasms
- Diabetes Mellitus
- Trematode Infections
- Traditional Serrated Adenoma
- Neurodegenerative Disorders
- Cardiovascular Diseases
- Neuroblastoma
- Nervous System Disorder
- Diabetes Mellitus, Non-insulin-dependent
- Obesity
- Liver Diseases
- Waldenstrom Macroglobulinemia
Pathways
- Aging
- Localization
- Urea Cycle
- Protein Deacetylation
- Dna Repair
- Gene Silencing
- Protein Acylation
- Protein Deacylation
- Energy Homeostasis
- Neuroprotection
- Protein Acetylation
- Secretion
- Transport
PTMs
- Deacetylation
- Acetylation
- Cleavage
Research Areas
- Epigenetics
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SIRT5
bosterbio.com/bosterbio-gene-info-cards/SIRT5
References
PMID: 10381378 by Frye R.A.; Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.
PMID: 16079181 by Michishita E., et al. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.