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- Table of Contents
SKP1 Antibodies
AND SKP1 ELISA kits, SKP1 Proteins
Many biological assays use antibodies to detect SKP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SKP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SKP1 antibodies...
Designing a Western blot for SKP1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SKP1 Western Blot GuideDesigning an IHC experiment for SKP1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SKP1 IHC GuideSKP1 Infographic by Boster Bio
All SKP1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00476-2
100 μg/vial
Cat # A00476-2
100 μg/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1524
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1524
1 kit, containing one 96-well plate and all necessary reagents
SKP1 Overview
Facts about S-phase kinase-associated protein 1.
S-phase kinase-associated protein 1 (SKP1)
Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. From the SCF complex, serves as an adapter that connects the F-box protein into CUL1.
The functional specificity of the SCF complex is based on the F-box protein as substrate recognition component. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and likely NFKB2 (PubMed:25704143).
Gene Information
| Human | |
|---|---|
| Gene Name: | SKP1 |
| Uniprot: | P63208 |
| Entrez: | 6500 |
Family
| Belongs to: |
|---|
| SKP1 family |
Alternative Names
Cyclin-A/CDK2-associated protein p19; EMC19p19skp1; MGC34403; OCP2; OCP2OCP-2; OCP-IIS-phase kinase-associated protein 1A (p19A); Organ of Corti protein 2; Organ of Corti protein II; p19a; p19Acyclin A/CDK2-associated p19; p19Skp1; RNA polymerase II elongation factor-like protein OCP2; RNA polymerase II elongation factor-like protein; SKP1; SKP1A; SKP1Acyclin A/CDK2-associated protein p19; S-phase kinase-associated protein 1; TCEB1LSIII; Transcription elongation factor B
Molecular Weight
Mass (kDA):
18.658 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q31.1 |
| Sequence: | 5; NC_000005.10 (134148935..134177033, complement) |
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Carcinoma
- Plant Diseases
- Von Hippel-lindau Syndrome
- Hypoxia
- Growth Arrest
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Virus Diseases
- Tissue Adhesions
- Retinoblastoma
Pathways
- Cell Cycle
- Proteolysis
- Cell Proliferation
- Localization
- S Phase
- Mitosis
- Cell Division
- Glycosylation
- Cell Cycle Arrest
- Conjugation
- Dna Replication
- Anaphase
- Cell Growth
PTMs
- Ubiquitination
- Phosphorylation
- Glycosylation
- Hydroxylation
- Dephosphorylation
Research Areas
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SKP1
bosterbio.com/bosterbio-gene-info-cards/SKP1
References
PMID: 7553852 by Zhang H., et al. p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase.
PMID: 8530064 by Sowden J., et al. A novel cDNA with homology to an RNA polymerase II elongation factors maps to human chromosome 5q31 (TCEB1L) and to mouse chromosome 11 (Tceb1l).