SLC12A2 Antibodies

AND SLC12A2 ELISA kits, SLC12A2 Proteins

Many biological assays use antibodies to detect SLC12A2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC12A2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC12A2 antibodies...

We validate the specificity of these antibodies to SLC12A2 by testing them on tissues known to express SLC12A2 positively and negatively. Browse below to find the SLC12A2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLC12A2 Infographic by Boster Bio

All SLC12A2 Products

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Anti-NKCC1/SLC12A2 Antibody Picoband®

2 Citations 5 Q&As

Western blot analysis of SLC12A2 using anti-SLC12A2 antibody (PA2169)

IHC analysis of SLC12A2 using anti-SLC12A2 antibody (PA2169)

Human, Mouse, Rat

IF, IHC, WB

$370
Cat # PA2169
100 μg/vial

Anti-NKCC1/SLC12A2 Antibody Picoband®

Western blot analysis of NKCC1/SLC12A2 using anti-NKCC1/SLC12A2 antibody (A03603)

IHC analysis of NKCC1/SLC12A2 using anti-NKCC1/SLC12A2 antibody (A03603)

Human, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A03603
100 μg/vial

Anti-NKCC1/SLC12A2 Antibody Picoband® (monoclonal, 6G7D2)

1 Citations

Western blot analysis of NKCC1/SLC12A2 using anti-NKCC1/SLC12A2 antibody (M03603)

IHC analysis of NKCC1/SLC12A2 using anti-NKCC1/SLC12A2 antibody (M03603)

Human, Mouse, Rat

IF, IHC, WB

$370
Cat # M03603
100 μg/vial

NKCC1 (SLC12A2) (NM_001046) Human Over-expression Lysate

Human

$960
Cat # LS006558
20 µg, 100 µg

SLC12A2 Overview

Facts about Solute carrier family 12 member 2.

SLC12A2 3D structure. Source: alphafold

Solute carrier family 12 member 2 (SLC12A2)

Electrically silent transporter system. Mediates sodium and chloride reabsorption.

Plays a vital role in the regulation of ionic balance and cell volume. .

Gene Information

Human
Gene Name:	SLC12A2
Uniprot:	P55011
Entrez:	6558

Family

Belongs to:

SLC12A transporter family

Alternative Names

Basolateral Na-K-Cl symporter; BSC; BSC2; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; NKCC1; NKCC1MGC104233; SLC12A2; solute carrier family 12 (sodium/potassium/chloride transporters), member 2; solute carrier family 12 member 2

Molecular Weight

Mass (kDA):
131.447 kDA

Genomic Context


Human

Location:	5q23.3
Sequence:	5; NC_000005.10 (128083766..128189677)

Tissue Specificity

Expressed in many tissues.

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

Complete Hearing Loss
Nervousness
Bartter Disease
Dysequilibrium Syndrome
Deafness Congenital
Schizophrenia
Hypertensive Disease
Limb Deformities, Congenital
Disease Of Adrenal Medulla
Metabolic Alkalosis
Malignant Neoplasm Of Breast
Infertility

Carcinoma
Fibrosis
Goiter
Malignant Neoplasms
Pain
Alkalosis
Cortisol 11-beta-ketoreductase Deficiency

Interacting Proteins

EZR
OXSR1

Pathways

Transport
Secretion
Insulin Secretion
Ion Transport
Response To Water Deprivation
Electron Transport
Brain Development
Fertilization
Immune Response
Pigmentation
Inner Ear Development
Spermatogenesis
Embryo Development

Swimming
Translation
Water Transport
Exocytosis
Chloride Transport
Ion Homeostasis
Ear Development

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC12A2

References

PMID: 7629105 by Payne J.A., et al. Primary structure, functional expression, and chromosomal localization of the bumetanide-sensitive Na-K-Cl cotransporter in human colon.

PMID: 11700976 by Vibat C.R., et al. Quantitation of Na(+)-K(+)-2Cl(-) cotransport splice variants in human tissues using kinetic polymerase chain reaction.