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- Table of Contents
Facts about MFS-type transporter SLC18B1.
Mouse | |
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Gene Name: | Slc18b1 |
Uniprot: | D3Z5L6 |
Entrez: | 76306 |
Belongs to: |
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major facilitator superfamily |
C6orf192; chromosome 6 open reading frame 192; dJ55C23.6; MFS-type transporter C6orf192; solute carrier family 18, subfamily B, member 1
Mass (kDA):
49.009 kDA
Mouse | |
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Location: | 10|10 A4 |
Sequence: | 10; |
Widely expressed, with highest expression in the lung, pancreas and kidney. High expression in the CNS, particularly in the hypothalamus, the thalamus and the cerebellum. In the forebrain, abundantly expressed in the telencephalon, especially in the cerebral cortex layers, except layer 1, as well as in the induseum griseum, the piriform area, the taenia tecta, dorsal part and in the entorhinal area, lateral part. Lower levels in the bed anterior olfactory nucleus, posteroventral part and in layer two of the olfactory tubercle. In the amygdala, high levels observed in the intercalated nucleus and the medial nucleus. In the diencephalon, expressed in the nuclei in both the hypothalamus and thalamus. Among the hypothalamic areas, strongest expression in the arcuate nucleus and in the ventromedial nucleus, as well as in the suprachiasmatic nucleus, anterior nucleus, especially in its central part, and in the magnocellular division of the paraventricular nucleus. In the thalamus, highest levels in the medial habenula. Expression also observed in the paraventricular thalamic nucleus, parataenial nucleus, central medial nucleus, intermediodorsal nucleus and lateral dorsal nucleus. In the
PMID: 19697161 by Jacobsson J.A., et al. C6ORF192 forms a unique evolutionary branch among solute carriers (SLC16, SLC17, and SLC18) and is abundantly expressed in several brain regions.