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- Table of Contents
Facts about Tricarboxylate transport protein, mitochondrial.
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Human | |
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Gene Name: | SLC25A1 |
Uniprot: | P53007 |
Entrez: | 6576 |
Belongs to: |
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mitochondrial carrier (TC 2.A.29) family |
Citrate transport protein; CTPTricarboxylate carrier protein; SEA; SLC20A3member 3; solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1; Solute carrier family 25 member 1; tricarboxylate transport protein, mitochondrial
Mass (kDA):
34.013 kDA
Human | |
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Location: | 22q11.21 |
Sequence: | 22; NC_000022.11 (19175575..19178863, complement) |
Mitochondrion inner membrane; Multi-pass membrane protein.
Look for antibodies that are validated across multiple platforms when selecting antibodies for your research. It is best to find antibodies that are highly specific, bind to target proteins with high affinity, and are therefore easy for others to validate. Boster also awards product credits to the initial reviewer of its products. All scientists can benefit from their efforts. These are the top uses of SLC25A1 marks.
The SLC25A1 enzyme plays a role in the redox-altered metabolism of cancer cells. This protein could be the metabolic "secret" to cancer. It is also associated with genomic instability. Its inhibition inhibits the self-renewal capability of CSCs. These findings are a boon on the field for cancer research.
SLC25A1 acts as a marker to regulate cell death. The process removes damaged and old cells, which helps to maintain normal homeostasis. This is a defensive mechanism as well as an immune response. Here are some tips to make your research successful using this marker. We'll discuss some of the benefits that SLC25A offers.
The intrinsic apoptosis pathway is an important player in promoting apoptosis. The pathway is activated if mitochondria become dysfunctional and release Cytochrome c. This activates caspases-3, and -9. Both caspases are responsible for cell death and DNA fracture. There are also several other pathways involved. Apoptosis-inducing compounds are found in cancer tumors.
TNF receptors can be found on cell surfaces and interact with TNF to recruit adaptors proteins. Fas-associated Protein with Death Domain and Tumor Narrowing Factor Receptor Type 1 Associated Death Domain are two examples. Additionally, downstream factors such caspase-8 play a significant role in the extrinsic pathways. The cells undergo apoptosis when this pathway is activated.
Biological assays often use antibodies to detect SLC25A1, a molecule involved in maintaining the citrate pool in mitochondria. SLC25A1 inhibition impairs cancer stem cells' (CSCs), ability to self-renew. Boster Bio's antibodies for SLC25A1 detect this marker in samples from mice and rats.
PMID: 8666394 by Heisterkamp N., et al. Localization of the human mitochondrial citrate transporter protein gene to chromosome 22q11 in the DiGeorge syndrome critical region.
PMID: 8660975 by Goldmuntz E., et al. Cloning, genomic organization, and chromosomal localization of human citrate transport protein to the DiGeorge/velocardiofacial syndrome minimal critical region.
*More publications can be found for each product on its corresponding product page