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- Table of Contents
Facts about Calcium-binding mitochondrial carrier protein SCaMC-2.
May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the web uptake or efflux of adenine nucleotides into or from the mitochondria. .
| Human | |
|---|---|
| Gene Name: | SLC25A25 |
| Uniprot: | Q6KCM7 |
| Entrez: | 114789 |

| Belongs to: |
|---|
| mitochondrial carrier (TC 2.A.29) family |

APC3; calcium-binding mitochondrial carrier protein SCaMC-2; KIAA1896RP11-395P17.4; MCSC; MCSC3; MGC105138; MGC119514; MGC119515; MGC119516; MGC119517; Mitochondrial ATP-Mg/Pi carrier protein 3; Mitochondrial Ca(2+)-dependent solute carrier protein 3; mitochondrial Ca2+-dependent solute carrier; PCSCL; SCAMC2; SCAMC-2; short calcium-binding mitochondrial carrier 2; small calcium-binding mitochondrial carrier 2; Small calcium-binding mitochondrial carrier protein 2; solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25; Solute carrier family 25 member 25; solute carrier
Mass (kDA):
52.663 kDA

| Human | |
|---|---|
| Location: | 9q34.11 |
| Sequence: | 9; NC_000009.12 (128068200..128109258) |
Present in various cell lines (at protein level). Widely expressed. Expressed in fetal and adult liver, skeletal muscle, testis, ovary, hippocampus and caudate nucleus. Isoform 1 is present in all tissues tested. Isoform 2 expression is restricted to kidney and lung.
Mitochondrion inner membrane; Multi-pass membrane protein.




PMID: 15054102 by del Arco A., et al. Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains.
PMID: 15123600 by Fiermonte G., et al. Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution.