Multidrug and toxin extrusion protein 1 (SLC47A1)

Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir as well as the zwitterionic cephalosporin, cephalexin and cephradin. Appears to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent).

Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs throughout the brush border membranes.