SLF1 Antibodies

AND SLF1 ELISA kits, SLF1 Proteins

Many biological assays use antibodies to detect SLF1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLF1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLF1 antibodies...

We validate the specificity of these antibodies to SLF1 by testing them on tissues known to express SLF1 positively and negatively. Browse below to find the SLF1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SLF1 Infographic by Boster Bio

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SLF1 Overview

Facts about SMC5-SMC6 complex localization factor protein 1.

SLF1 3D structure. Source: alphafold

SMC5-SMC6 complex localization factor protein 1 (SLF1)

Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to connect RAD18 using the SMC5-SMC6 complex at replication- coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565).

Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions (PubMed:25931565). .

Gene Information

Human
Gene Name:	SLF1
Uniprot:	Q9BQI6
Entrez:	84250

Family

Belongs to:

No superfamily

Alternative Names

SMC5-SMC6 complex localization factor protein 1

Molecular Weight

Mass (kDA):
121.05 kDA

Genomic Context


Human

Location:	5q15
Sequence:	5; NC_000005.10 (94613476..94714918)

Subcellular Localizations

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Relocalizes with RAD18 to nuclear foci in response to DNA damage. Colocalizes with RAD18 in the nucleus and to centrosomes (By similarity). Associates with chromatin (PubMed:25931565). Accumulates with RAD18 and the SMC5-SMC6 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565).

PTMs

Isopeptide bond

Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLF1

References

PMID: 25931565 by Raeschle M., et al. DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links.