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SLF2 Antibodies
AND SLF2 ELISA kits, SLF2 Proteins
Many biological assays use antibodies to detect SLF2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLF2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLF2 antibodies...
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SLF2 Overview
Facts about SMC5-SMC6 complex localization factor protein 2.
SMC5-SMC6 complex localization factor protein 2 (SLF2)
Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complicated acts to connect RAD18 using the SMC5-SMC6 complex at replication- coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565).
Promotes the recruitment of this SMC5-SMC6 complex to DNA lesions (PubMed:25931565). .
Gene Information
| Human | |
|---|---|
| Gene Name: | SLF2 |
| Uniprot: | Q8IX21 |
| Entrez: | 55719 |
Family
| Belongs to: |
|---|
| FAM178 family |
Alternative Names
SMC5-SMC6 complex localization factor protein 2
Molecular Weight
Mass (kDA):
131.873 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q24.31 |
| Sequence: | 10; NC_000010.11 (100909416..100965134) |
Tissue Specificity
Widely expressed (PubMed:12459258). Expressed at higher level in skeletal muscle and at slightly lower level in brain, liver and heart, than in lung, kidney, spleen and thymus (PubMed:12459258).
Subcellular Localizations
Nucleus. Mainly localizes in the nucleus (PubMed:24561620). Colocalizes with PCNA on replication sites (PubMed:24561620). Associates with chromatin (PubMed:25931565). Accumulates with RAD18 and the SMC5-SMC6 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565).
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLF2
bosterbio.com/bosterbio-gene-info-cards/SLF2
References
PMID: 12459258 by Nikali K., et al. cDNA cloning, expression profile and genomic structure of a novel human transcript on chromosome 10q24, and its analyses as a candidate gene for infantile onset spinocerebellar ataxia.
PMID: 24561620 by Alabert C., et al. Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components.