Schlafen family member 8 Antibodies

AND Slfn8 ELISA kits, Schlafen family member 8 Proteins

Many biological assays use antibodies to detect Schlafen family member 8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Schlafen family member 8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Schlafen family member 8 antibodies...

We validate the specificity of these antibodies to Schlafen family member 8 by testing them on tissues known to express Slfn8 positively and negatively. Browse below to find the Slfn8 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Slfn8 Overview

Facts about Schlafen family member 8.

Slfn8 3D structure. Source: alphafold

Schlafen family member 8 (Slfn8)

Endoribonuclease that cleaves tRNAs and rRNAs (PubMed:29563550). Cleaves tRNAs 11 nucleotides in the 3'- terminus at the acceptor stem (PubMed:29563550).

May be involved in immune system via regulation of inflammation (PubMed:29528433). .

Gene Information

Mouse
Gene Name:	Slfn8
Uniprot:	B1ARD8
Entrez:	276950

Family

Belongs to:

Schlafen family

Alternative Names

Schlafen family member 8

Molecular Weight

Mass (kDA):
104.264 kDA

Genomic Context


Mouse

Location:	11\|11 C
Sequence:	11;

Tissue Specificity

In T-cells, expressed at relatively constant levels during development: expressed in immature CD3(-)CD4(-)CD8(-) T-cells (DN stage), in CD4(+)CD8(+) double- positive stage (DP) and mature CD4(+) or CD8(+) thymocytes. Expression is slightly reduced at the DP stage.

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Slfn8

References

PMID: 15351786 by Geserick P., et al. Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif.

PMID: 29528433 by Nakagawa K., et al. Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis.