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- Table of Contents
SMARCB1 Antibodies
AND SMARCB1 ELISA kits, SMARCB1 Proteins
Many biological assays use antibodies to detect SMARCB1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMARCB1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMARCB1 antibodies...
Designing a Western blot for SMARCB1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SMARCB1 Western Blot GuideSMARCB1 Infographic by Boster Bio
All SMARCB1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC, ICC, WB
$370
Cat # A00500-2
100 μg/vial
Cat # A00500-2
100 μg/vial
SMARCB1 Overview
Facts about SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1.
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1)
Core part of the BAF (hSWI/SNF) complicated. This ATP- dependent chromatin-remodeling complicated plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation.
The BAF complex is able to make a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of around one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers.
Gene Information
| Human | |
|---|---|
| Gene Name: | SMARCB1 |
| Uniprot: | Q12824 |
| Entrez: | 6598 |
Family
| Belongs to: |
|---|
| SNF5 family |
Alternative Names
BAF47; BAF47hSNF5; BRG1-associated factor 47; hSNFS; Ini1; INI1RTPS1; Integrase interactor 1 protein; malignant rhabdoid tumor suppressor; RDTSNF5 homolog; Sfh1p; SNF5; SNF5L1; Snr1; subfamily b, member 1; sucrose nonfermenting, yeast, homolog-like 1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin; SWI/SNF-related matrix-associated actin-dependent regulator of chromatinsubfamily B member 1
Molecular Weight
Mass (kDA):
44.141 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q11.23|22q11 |
| Sequence: | 22; NC_000022.11 (23786966..23838009) |
Subcellular Localizations
Nucleus.
Diseases
- Neoplasms
- Rhabdoid Tumor
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasms
- Brain Neoplasms
- Atypical Teratoid/rhabdoid Tumor
- Nervousness
- Teratoma
- Sarcoma
- Carcinoma
- Cell Transformation, Neoplastic
- Neurilemmoma
- Schwannomatosis
Interacting Proteins
- ARID2
- CALR
- SMARCA4
- Smarca4
Pathways
- Chromatin Remodeling
- Cell Cycle
- Pathogenesis
- Atp-dependent Chromatin Remodeling
- Cell Cycle Arrest
- Cell Growth
- Cell Proliferation
- Senescence
- Oncogenesis
- Rna Interference
- Methylation
- Reverse Transcription
PTMs
- Phosphorylation
- Methylation
- Acetylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMARCB1
bosterbio.com/bosterbio-gene-info-cards/SMARCB1
References
PMID: 7801128 by Kalpana G.V., et al. Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5.
PMID: 9671307 by Versteege I., et al. Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer.