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- Table of Contents
Facts about Telomerase-binding protein EST1A.
Promotes in vitro the ability of TERT to elongate telomeres (PubMed:12676087, PubMed:12699629). Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization (PubMed:12676087, PubMed:12699629).
| Human | |
|---|---|
| Gene Name: | SMG6 |
| Uniprot: | Q86US8 |
| Entrez: | 23293 |

| Belongs to: |
|---|
| No superfamily |

C17orf31; EST1 telomerase component homolog A; EST1A; EST1-like protein A; ever shorter telomeres 1A; hSmg5/7a; KIAA0732; smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans); SMG-6; telomerase subunit EST1A; telomerase-binding protein EST1A
Mass (kDA):
160.462 kDA

| Human | |
|---|---|
| Location: | 17p13.3 |
| Sequence: | 17; NC_000017.11 (2059839..2303836, complement) |
Ubiquitous.
Nucleus, nucleolus. Chromosome, telomere. Cytoplasm, cytosol. Particularly enriched in the nucleolus.




PMID: 12676087 by Reichenbach P., et al. A human homolog of yeast est1 associates with telomerase and uncaps chromosome ends when overexpressed.
PMID: 12699629 by Snow B.E., et al. Functional conservation of the telomerase protein Est1p in humans.