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- Table of Contents
SMPD1 Antibodies
AND SMPD1 ELISA kits, SMPD1 Proteins
Many biological assays use antibodies to detect SMPD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMPD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMPD1 antibodies...
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SMPD1 Infographic by Boster Bio
All SMPD1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK2025
96 wells/kit, with removable strips.
Cat # EK2025
96 wells/kit, with removable strips.
Human
IHC, WB
$523
Cat # M00752
100 µl
Cat # M00752
100 µl
Human
$960
Cat # LS006609
20 µg, 100 µg
Cat # LS006609
20 µg, 100 µg
Human, Monkey, Mouse, Rat
IHC, WB
$370
Cat # M00752-1
100 μl/vial
Cat # M00752-1
100 μl/vial
SMPD1 Overview
Facts about Sphingomyelin phosphodiesterase.
Sphingomyelin phosphodiesterase (SMPD1)
Converts sphingomyelin to ceramide (PubMed:1840600, PubMed:18815062, PubMed:27659707, PubMed:25920558). Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | SMPD1 |
| Uniprot: | P17405 |
| Entrez: | 6609 |
Family
| Belongs to: |
|---|
| acid sphingomyelinase family |
Alternative Names
Acid sphingomyelinase; aSMase; ASMsphingomyelin phosphodiesterase; EC 3.1.4.12; NPD; SMPD1; sphingomyelin phosphodiesterase 1, acid lysosomal
Molecular Weight
Mass (kDA):
69.936 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p15.4 |
| Sequence: | 11; NC_000011.10 (6390474..6394998) |
Subcellular Localizations
Lysosome. Secreted.
Diseases
- Niemann-pick Diseases
- Aggressive Systemic Mastocytosis
- Niemann-pick Disease, Type B
- Niemann-pick Disease, Type A
- Neoplasms
- Malignant Neoplasms
- Pick Disease Of The Brain
- Beckwith-wiedemann Syndrome
- Ataxia
- Inflammation
- Coronary Artery Disease
- Congenital Hemihypertrophy
Interacting Proteins
- CASP7
Pathways
- Cell Death
- Lipid Storage
- Localization
- Cholesterol Efflux
- Vasodilation
- Regulation Of Growth
- Neurogenesis
- Metaphase
- Keratinocyte Differentiation
- Membrane Fusion
- Decidualization
- Regeneration
PTMs
- Cleavage
Research Areas
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMPD1
bosterbio.com/bosterbio-gene-info-cards/SMPD1
References
PMID: 1840600 by Schuchman E.H., et al. Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs.
PMID: 1292508 by Newrzella D., et al. Molecular cloning of the acid sphingomyelinase of the mouse and the organization and complete nucleotide sequence of the gene.